Indian Journal of Critical Care Case Report

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VOLUME 3 , ISSUE 4 ( July-August, 2024 ) > List of Articles


Management of a Case of Toxic Epidermal Necrolysis in Intensive Care Unit

Shivangi Mishra, Ashirwad Dubey, KT Radhika, Shridhar Gidaganti, Jinay Gala, Harish M Maheshwarappa

Keywords : Case report, Cyclosporine, Mucocutaneous syndrome, Phenytoin, Toxic epidermal necrolysis

Citation Information : Mishra S, Dubey A, Radhika K, Gidaganti S, Gala J, Maheshwarappa HM. Management of a Case of Toxic Epidermal Necrolysis in Intensive Care Unit. 2024; 3 (4):114-116.

DOI: 10.5005/jp-journals-11006-0119

License: CC BY-NC 4.0

Published Online: 21-06-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Toxic epidermal necrolysis (TEN) is a life-threatening acute mucocutaneous syndrome with high mortality. It usually occurs because of adverse immune reactions to certain drugs. It is characterized by the necrosis of keratinocytes and the separation of the epidermis from the underlying dermis. TEN is a rare disorder with high mortality (30% of cases). A 42-year-old female with preexisting seizure disorder presented with generalized exanthema, increasing exfoliation, mucosal, and ocular involvement after intake of phenytoin as an antiepileptic agent. Clinical diagnosis of TEN was made with the involvement of around 80% of the total body surface area. Early treatment was started with dexamethasone along with cyclosporine for 10 days. Early diagnosis, management, fluid resuscitation, prevention of hypothermia, nutrition, analgosedation, thromboprophylaxis, pain control, good aseptic practices, and amniotic membrane transplantation helped in quick recovery and nearly complete healing of the wounds.

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