Indian Journal of Critical Care Case Report

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VOLUME 3 , ISSUE 3 ( May-June, 2024 ) > List of Articles

CASE REPORT

Influenza-induced Pancreatitis and Pancreatic Encephalopathy: A Rare Clinical Presentation

Swetha Narayanan, G Jithesh, Madhav Banjade, Mukesh Bairwa

Keywords : Case report, Influenza, Pancreatitis, Pancreatic encephalopathy

Citation Information : Narayanan S, Jithesh G, Banjade M, Bairwa M. Influenza-induced Pancreatitis and Pancreatic Encephalopathy: A Rare Clinical Presentation. 2024; 3 (3):81-82.

DOI: 10.5005/jp-journals-11006-0102

License: CC BY-NC 4.0

Published Online: 03-05-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Abstract

Instances of the H1N1 influenza virus contributing to acute pancreatitis (AP) are indeed rare. Similarly, pancreatic encephalopathy (PE) represents an unusual complication of AP that is often underdiagnosed and unreported. Here, we present a unique case involving influenza-induced pancreatitis and subsequent PE in a middle-aged female who initially presented with acute shortness of breath, complaints of abdominal pain, and altered sensorium. A nasopharyngeal reverse transcription polymerase chain reaction (RT-PCR) for influenza A confirmed the infection with H1N1. Ultrasonography of the abdomen and contrast-enhanced computed tomography revealed features indicative of AP. Due to the altered sensorium, a noncontrast computed tomography (NCCT) of the brain was conducted, yielding normal results. Cerebrospinal fluid (CSF) analysis also returned normal results. With a regimen of conservative management for pancreatitis and treatment with oseltamivir, the patient experienced improvement in both shortness of breath and sensorium. This case underscores the unusual manifestation of influenza-related complications and emphasizes the significance of a multidisciplinary approach to diagnosis and management.


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  1. Parenti DM, Steinberg W, Kang P. Infectious causes of acute pancreatitis. Pancreas 1996;13(4):356–371. DOI: 10.1097/00006676-199611000-00005
  2. Sarshari B, Zareh-Khoshchehreh R, Keshavarz M, et al. The possible role of viral infections in acute pancreatitis: a review of literature. Gastroenterol Hepatol Bed Bench 2023;16(3):270–281. DOI: 10.22037/ghfbb.v16i2.2582
  3. Sun GH, Yang YS, Liu QS, et al. Pancreatic encephalopathy and Wernicke encephalopathy in association with acute pancreatitis: a clinical study. World J Gastroenterol 2006;12(26):4224–4227. DOI: 10.3748/wjg.v12.i26.4224
  4. Blum A, Podvitzky O, Shalabi R, et al. Acute pancreatitis may be caused by H1N1 influenza A virus infection. Isr Med Assoc J 2010;12(10):640–641.
  5. Baran B, Karaca C, Soyer OM, et al. Acute pancreatitis associated with H1N1 influenza during 2009 pandemic: a case report. Clin Res Hepatol Gastroenterol 2012;36(4):e69–e70. DOI: 10.1016/j.clinre.2012.01.002
  6. Capua I, Mercalli A, Pizzuto MS, et al. Influenza A viruses grow in human pancreatic cells and cause pancreatitis and diabetes in an animal model. J Virol 2013;87(1):597–610. DOI: 10.1128/JVI.00714-12
  7. Huo C, Xiao K, Zhang S, et al. H5N1 Influenza a virus replicates productively in pancreatic cells and induces apoptosis and pro-inflammatory cytokine response. Front Cell Infect Microbiol 2018;8:386. DOI: 10.3389/fcimb.2018.00386
  8. Mittal S, Mittal S, Govil T. The uncommon syndrome of pancreatic encephalopathy. Astrocyte 2016;2(4):185–186. DOI: 10.4103/2349-0977.191047
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