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VOLUME 2 , ISSUE 6 ( November-December, 2023 ) > List of Articles


Life-threatening Diffuse Alveolar Hemorrhage in a Patient with Systemic Lupus Erythematosus and Antiphospholipid Syndrome

Deven Juneja, Omender Singh, Joy D Mukherji, Rahul Grover, Tarun Sharma

Keywords : Alveolar hemorrhage, Antiphospholipid antibodies, Antiphospholipid syndrome, Case report, Pulmonary hemorrhage, Rituximab, Systemic lupus erythematosus

Citation Information : Juneja D, Singh O, Mukherji JD, Grover R, Sharma T. Life-threatening Diffuse Alveolar Hemorrhage in a Patient with Systemic Lupus Erythematosus and Antiphospholipid Syndrome. 2023; 2 (6):168-171.

DOI: 10.5005/jp-journals-11006-0082

License: CC BY-NC 4.0

Published Online: 01-12-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Introduction: Autoimmune diseases may have myriad presentations and may sometimes present with life-threatening systemic complications. Here, we present a case who presented with massive hemoptysis and was diagnosed to have systemic lupus erythematosus (SLE) with secondary antiphospholipid syndrome (APS) and diffuse alveolar hemorrhage (DAH). Case description: A 45-year-old female, a known case of hypertension and seizure disorder, presented with a 1-day history of breathlessness and hemoptysis. She required intubation and invasive mechanical ventilation in view of massive hemoptysis and high oxygen requirement. Subsequent investigations confirmed the diagnosis of SLE with secondary APS and DAH, and she was treated with pulse dose corticosteroids and rituximab with a favorable outcome. Conclusion: SLE and APS may rarely present with bleeding complications like DAH. Hence, a high index of suspicion must be kept as early therapy with immunosuppressants like high-dose corticosteroids and rituximab may lead to good clinical outcomes.

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