Indian Journal of Critical Care Case Report

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VOLUME 2 , ISSUE 3 ( May-June, 2023 ) > List of Articles


Phenytoin Overdose-induced Rhabdomyolysis: A Rare Case Report

Neeraja Vijayan, Nakka Vihari, Mohd Nadeem, Naresh K Midha, Varatharajan Sakthivadivel, MK Garg

Keywords : Acute kidney injury, Phenytoin, Rhabdomyolysis

Citation Information : Vijayan N, Vihari N, Nadeem M, Midha NK, Sakthivadivel V, Garg M. Phenytoin Overdose-induced Rhabdomyolysis: A Rare Case Report. 2023; 2 (3):69-71.

DOI: 10.5005/jp-journals-11006-0054

License: CC BY-NC 4.0

Published Online: 26-06-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Introduction: Phenytoin is the commonly used antiepileptic medication for abortive as well as maintenance therapy. Even though phenytoin is associated with various side effects, only a few cases of phenytoin-induced rhabdomyolysis have been reported so far. Most cases are either due to parenteral use for status epilepticus or hypersensitivity reaction to maintenance therapy. Case description: We present an 18-year-old male, on regular treatment for a seizure disorder, who presented with altered sensorium following ingestion of 15–20 tablets of phenytoin (1500–2000 mg) and was found to have acute kidney injury (AKI) due to rhabdomyolysis secondary to phenytoin toxicity. The patient recovered completely with hemodialysis and supportive care. Conclusion: Phenytoin overdose-induced rhabdomyolysis is a rare occurrence with high risk of acute kidney injury. Awareness of clinicians about this rare complication is helpful for early diagnosis and treatment.

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