Introduction: Infective endocarditis is an emerging disease in ICU settings with high morbidity and in hospital mortality of up to 20%. Staphylococci and Streptococci are the most common organism causing the disease. Diagnosis and management of Infective endocarditis is challenging because of the pre-existing illness and complex nature of the disease at presentation to ICU. Case description: We present, a rare case of double valve infective endocarditis in a 48-year-old diabetic patient with Burkholderia cepacia infection who presented as febrile illness with cardio-respiratory failure. This organism is gaining importance with the increasing rate of nosocomial infections. In view of virulent multi-drug resistant organism, large vegetations, cardiogenic shock and dual valve involvement, patient underwent surgical intervention along with prolonged course of appropriate antibiotic therapy. Discussion: Burkholderia cepacia infections are rare and are usually nosocomial, multi-drug resistant and commonly causing infections only in the immunocompromised hosts, patients with granulomatous disease and hospitalized patients. Management includes correct identification with high index of suspicion, appropriate antibiotic with early surgical intervention, especially in the setting of a complicated Infective endocarditis, as seen in our case. Conclusion: A multidisciplinary team approach with antibiotics and appropriate timing of surgery helps to reduce morbidity, mortality and improves clinical outcomes.