Indian Journal of Critical Care Case Report

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VOLUME 3 , ISSUE 2 ( March-April, 2024 ) > List of Articles


Severe Cotrimoxazole-induced Hypoglycemia in a Patient with Pneumocystis jirovecii Pneumonia: A Case Report

Swarna D Kuragayala, Samantha Sathyakumar, Hima B Kotamarthy

Keywords : Cotrimoxazole, Hypoglycemia, Pneumocystis jirovecii pneumonia

Citation Information : Kuragayala SD, Sathyakumar S, Kotamarthy HB. Severe Cotrimoxazole-induced Hypoglycemia in a Patient with Pneumocystis jirovecii Pneumonia: A Case Report. 2024; 3 (2):43-45.

DOI: 10.5005/jp-journals-11006-0093

License: CC BY-NC 4.0

Published Online: 15-03-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Aim: To report a case of prolonged severe hypoglycemia associated with cotrimoxazole in a nondiabetic human immunodeficiency syndrome (HIV)—positive patient. Case description: We describe a case of cotrimoxazole-associated hypoglycemia in a 30-year-old nondiabetic HIV-positive patient. The patient developed hypoglycemia after she was started on cotrimoxazole for the treatment of Pneumocystis jirovecii. Her renal and hepatic function was normal. Serum insulin and C-peptide measured at the time of hypoglycemia were found to be significantly elevated. Hypoglycemia was managed with intravenous administration of dextrose and resolved after cotrimoxazole was withdrawn. We also review the literature regarding this uncommon adverse effect of the commonly used drug.

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