Keywords :
Candida pelliculosa, Case report, Echinocandins, Outbreak, Intensive care unit
Citation Information :
Yadav S, Jain V, Khatri M, Nare T. Candida pelliculosa Infection in Adults Admitted in Intensive Care Unit of Tertiary Care Center: Should We Treat or Not?. 2023; 2 (5):124-127.
Introduction:Candida pelliculosa (C. pelliculosa) infection has been reported as an agent of healthcare-associated candidemia in the neonatal intensive care unit (ICU) but is less commonly reported in critically ill adults.
Case description: We reported two cases in our adult ICU who were found to have this uncommon infection. The first patient was a 25-year-old female with preeclampsia who underwent emergency lower segment cesarean section (LSCS) for abruption placentae and showed signs of sepsis. On examining her blood cultures, we could isolate C. pelliculosa and start her on anti-fungal treatment, to which she responded appropriately. The second case was of a 57-year-old male with pituitary apoplexy on steroid therapy whose surveillance blood culture was also flagged for C. pelliculosa. However, he was not started on any treatment. We try to discuss the difference in approach to treatment in both cases, though they flagged for the same organism.
Conclusion: These cases further emphasize the necessity of source control, as C. pelliculosa infection has been linked to outbreaks.
Lin HC, Lin HY, Su BH, et al. Reporting an outbreak of Candida pelliculosa fungemia in a neonatal intensive care unit. J Microbiol Immunol Infect 2013;46(6):456–462. DOI: 10.1016/j.jmii.2012.07.013
Zhang Z, Cao Y, Li Y, et al. Risk factors and biofilm formation analyses of hospital-acquired infection of Candida pelliculosa in a neonatal intensive care unit. BMC Infect Dis 2021;21(1):620. DOI: 10.1186/s12879-021-06295-1
Pratt JJ, Niedle PS, Vogel JP, et al. Alternative regimens of magnesium sulfate for treatment of preeclampsia and eclampsia: a systematic review of non-randomized studies. Acta Obstet Gynecol Scand 2016;95(2):144–156. DOI: 10.1111/aogs.12807
Song KY, Park C, Byun JH, et al. Fungal arthritis with adjacent osteomyelitis caused by Candida pelliculosa: a case report. BMC Infect Dis 2020;20(1):438. DOI: 10.1186/s12879-020-05171-8
Kang SJ, Jang MO, Jang HC, et al. A case of candida pelliculosa prosthetic valve endocarditis treated with anidulafungin and valve replacement. Infect Chemother 2012;44(6):499–503. DOI: 10.3947/ic.2012.44.6.499
Kojic EM, Darouiche RO. Candida infections of medical devices. Clin Microbiol Rev 2004;17(2):255–267. DOI: 10.1128/CMR.17.2.255-267.2004
Kalkanci A, Dizbay M, Turan O, et al. Nosocomial transmission of Candida pelliculosa fungemia in a pediatric intensive care unit and review of the literature. Turk J Pediatr 2010;52(1):42–49. PMID: 20402066.
Pappas PG, Kauffman CA, Andes DR, et al. Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis 2016;62(4):e1–50. DOI: 10.1093/cid/civ933
Zhang L, Xiao M, Arastehfar A, et al. Investigation of the emerging nosocomial wickerhamomyces anomalus infections at a Chinese Tertiary Teaching Hospital and a systemic review: clinical manifestations, risk factors, treatment, outcomes, and anti-fungal susceptibility. Front Microbiol 2021;12:744502. DOI: 10.3389/fmicb.2021.744502
Chan AW, Cartwright EJ, Reddy SC, et al. Pichia anomala (Candida pelliculosa) fungemia in a patient with sickle cell disease. Mycopathologia 2013;176(3-4):273–277. DOI: 10.1007/s11046-013-9677-5
Yang Y, Wu W, Ding L, et al. Two different clones of Candida pelliculosa bloodstream infection in a tertiary neonatal intensive care unit. J Infect Dev Ctries 2021;15(6):870–876. DOI: 10.3855/jidc.12103