Indian Journal of Critical Care Case Report

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VOLUME 2 , ISSUE 4 ( July-August, 2023 ) > List of Articles


Immobilization-induced Hypercalcemia in a Critically Ill Adult: A Case Report

Kamil Inci, Lale Karabiyik

Keywords : Case report, Hypercalcemia, Hypoxıc ischemic encephalopathy, Intensive care unit

Citation Information : Inci K, Karabiyik L. Immobilization-induced Hypercalcemia in a Critically Ill Adult: A Case Report. 2023; 2 (4):110-112.

DOI: 10.5005/jp-journals-11006-0068

License: CC BY-NC 4.0

Published Online: 18-08-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Immobilization-induced hypercalcemia (IIH) is a rarely seen condition of which etiology is unclear. It has been described as a complication in adult patients with prolonged movement limitations depending on severe acute trauma, multiple bone fractures, and stroke or young adults with immobilization depending on spinal cord injuries. Diagnosis requires a detailed evaluation to exclude other conditions causing hypercalcemia. This is a case report of a 64-year-old male with prolonged immobilization related to hypoxic brain injury who presented with severe hypercalcemia and contributed to identifying hypercalcemia as a result of immobilization.

  1. Endres DB. Investigation of hypercalcemia. Clin Biochem 2012;45(12):954–963. DOI: 10.1016/j.clinbiochem.2012.04.025
  2. Lafferty FW. Differential diagnosis of hypercalcemia. J Bone Miner Res 1991;6(Suppl 2):S51–59. DOI: 10.1002/jbmr.5650061413
  3. Burtis WJ, Wu TL, Insogna KL, et al. Humoral hypercalcemia of malignancy. Ann Intern Med 1988;108(3):454–457. DOI: 10.7326/0003-4819-108-3-454
  4. Albright F, Burnett CH, Cope O, et al. Acute atrophy of bone (osteoporosis) simulating hyperparathyroidism. J Clin Endocrinol 1941;1(9):711–716. DOI: 10.1210/jcem-1-9-711
  5. Major P, Lortholary A, Hon J, et al. Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: a pooled analysis of two randomized, controlled clinical trials. J Clin Oncol 2001;19(2):558–567. DOI: 10.1200/JCO.2001.19.2.558
  6. Booth KA, Hays CI. Using denosumab to threat immobilization hypercalcemia in a post-acute care patient. J Clin Endocrinol Metab 2014;99(10):3531–3535. DOI: 10.1210/jc.2013-4205
  7. Yusuf MB, Akinyoola AL, Orimolade AE, et al. Determinants of hypercalcemia and hypercalciuria in immobilized trauma patients. Bonekey Rep 2015;4:709. DOI: 10.1038/bonekey.2015.78
  8. Whyte MP, Leelawattana R, Reinus WR, et al. Acute severe hypercalcemia after traumatic fractures and immobilization in hypophosphatasia complicated by chronic renal failure. J Clin Endocrinol Metab 2013;98(12):4606–4612. DOI: 10.1210/jc.2013-1811
  9. Cano-Torres EA, González-Cantú A, Hinojosa-Garza G, et al. Immobilization induced hypercalcemia. Clin Case Miner Bone Metabol 2016;13(1):46–47. DOI: 10.11138/ccmbm/2016.13.1.046
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