Indian Journal of Critical Care Case Report

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VOLUME 2 , ISSUE 4 ( July-August, 2023 ) > List of Articles


Delayed Osmotic Demyelination Syndrome Treated Successfully with Therapeutic Plasma Exchange: A Case Report

Aarthee Asokan, Dhanaraj Mathuram, Mark A Augustus

Keywords : Case report, Central pontine myelinolysis, Extra pontine myelinolysis, Osmotic demyelination syndrome

Citation Information : Asokan A, Mathuram D, Augustus MA. Delayed Osmotic Demyelination Syndrome Treated Successfully with Therapeutic Plasma Exchange: A Case Report. 2023; 2 (4):91-93.

DOI: 10.5005/jp-journals-11006-0063

License: CC BY-NC 4.0

Published Online: 18-08-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Osmotic demyelination syndrome (ODS) is an uncommon neurological disorder, generally following rapid correction of hyponatremia resulting in demyelination of the white matter of the pons and certain extrapontine regions. The neurological symptomatology can vary from mild confusion to severe dense global paralysis, coma, or death. Once ODS is established, there is no proven treatment. Several experimental therapies, such as reinduction of hyponatremia, intravenous immunoglobulin (IVIG), plasma exchange, and steroids, have been tried with variable success. In this case report, we describe a case of ODS with global paralysis that responded well to plasma exchange therapy despite a full month has passed since the onset of symptoms. This is probably one of the first few cases reported from this part of the country.

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