Indian Journal of Critical Care Case Report

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VOLUME 2 , ISSUE 4 ( July-August, 2023 ) > List of Articles


Therapeutic Conundrum: Infective Endocarditis due to Extensively Drug-resistant Pseudomonas aeruginosa Treated with Ceftazidime/Avibactam Monotherapy: A Case Report

Preeti Ajapuje, Sampada Patwardhan, Romika Dawra, Shireesh Sathe, Dhairyasheel Kanase, Narendra Javdekar, Nilesh Juvekar, Advait Melinkeri, Amrita Prayag

Keywords : Carbapenem-resistant, Case report, Pseudomonas aeruginosa infective endocarditis, Ceftazidime/Avibactam, Gram-negative infective endocarditis, Infective endocarditis

Citation Information : Ajapuje P, Patwardhan S, Dawra R, Sathe S, Kanase D, Javdekar N, Juvekar N, Melinkeri A, Prayag A. Therapeutic Conundrum: Infective Endocarditis due to Extensively Drug-resistant Pseudomonas aeruginosa Treated with Ceftazidime/Avibactam Monotherapy: A Case Report. 2023; 2 (4):88-90.

DOI: 10.5005/jp-journals-11006-0061

License: CC BY-NC 4.0

Published Online: 18-08-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Infective endocarditis (IE) is a significant cause of mortality and morbidity, especially in patients with underlying acquired structural heart disease in developing countries. IE caused by non-Haemophilus, Aggregatibacter, Cardiobacterium, Eikenella, Kingella (HACEK) gram-negative bacteria (GNB) accounts for approximately 2% of all cases and is characterized by high mortality. Pseudomonas aeruginosa (P. aeruginosa) IE accounts for <0.4% of all endocarditis cases. Gram-negative endocarditis is further compounded by the problem of antimicrobial resistance. We report a very rare case of carbapenem-resistant P. aeruginosa IE (CRIE) from India to highlight the difficulties of managing such cases with the challenges of antimicrobial resistance in our settings.

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