Background: Despite recent advancements, patients with sepsis and septic shock continue to have high morbidity and mortality. Appropriate empiric antimicrobials form the cornerstone of therapeutic interventions and are vital for improving patient outcomes. Rare infections may sometimes complicate clinical diagnosis and make a choice of empiric antimicrobials challenging. Hence, recognition of rare infections and their antimicrobial susceptibility pattern is imperative for the management of such cases. Case description: Comamonas spp. are common environmental nonfermentative gram-negative bacilli that occasionally cause human disease. Human infections are not usually life-threatening. We present a case of bacteremia secondary to Comamonas testosteroni (C. testosteroni) in a 35 years old patient with chronic liver disease (CLD). Conclusion: Comamonas testosteroni (C. testosteroni) is an emerging human pathogen and may rarely cause sepsis and septic shock, especially in immunocompromised patients. The sensitivity pattern and choice of antibiotics need to be further evaluated for this rare infection, as early appropriate therapy may affect outcomes.