We hereby report the first case in the Indian subcontinent to the best of our knowledge of dual infection of disseminated histoplasmosis in an immunocompetent host with coronavirus disease 2019 (COVID-19) infection. We herein report a case of a 22-year-old COVID-19-positive immunocompetent male who presented with fever, breathing difficulty, pancytopenia, and skin exanthem. The bone marrow and skin biopsy established the diagnosis of disseminated histoplasmosis. The case was successfully treated with amphotericin and itraconazole. Diagnosis of opportunistic or coinfection infection in COVID-19 patients requires a high-index of suspicion, especially in immunocompetent patients.
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