Yeasts such as Trichosporon are being increasingly reported in catheterized urine of hospitalized patients. However, guidelines to interpret their clinical significance are lacking. The following case highlights the need for research and evidence-based recommendations for the management of funguria, especially for Trichosporon in urine for critically ill patients with nonresolving sepsis. This is a case of metastatic carcinoma lung on immunotherapy, which developed nonresolving sepsis along with repeated isolation of Trichosporon from urine. Patient had shown clinical response only after treatment with voriconazole.
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