Indian Journal of Critical Care Case Report

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VOLUME 1 , ISSUE 3 ( November-December, 2022 ) > List of Articles


Reversible Platypnea-orthodeoxia Syndrome in COVID-19: A Sparsely Reported Entity

Avishek Layek

Keywords : Coronavirus disease 2019, Orthodeoxia, Platypnea, Platypnea-orthodeoxia syndrome

Citation Information : Layek A. Reversible Platypnea-orthodeoxia Syndrome in COVID-19: A Sparsely Reported Entity. 2022; 1 (3):82-86.

DOI: 10.5005/jp-journals-11006-0027

License: CC BY-NC 4.0

Published Online: 02-01-2023

Copyright Statement:  Copyright © 2022; The Author(s).


Platypnea-orthodeoxia syndrome (POS) is a sparingly documented symptom in the spectrum of the coronavirus disease 2019 (COVID-19) manifestations, which can manifest with a variety of symptoms, ranging from a minor flu-like sickness to lethal severe acute respiratory distress syndrome (ARDS). In two cases with severe COVID-19 pneumonia that we saw POS in, both patients stated that their POS symptoms had resolved on follow-up after 4 weeks of conservative treatment. The pathophysiology of POS may be explained by gravitational redistribution of pulmonary blood flow, which results in enhanced basal arteriovenous shunting and upper zone dead space ventilation in some cases with severe COVID-19 disease due to their predominant involvement of basal parts of lung parenchyma.

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