Indian Journal of Critical Care Case Report

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VOLUME 1 , ISSUE 2 ( September-October, 2022 ) > List of Articles


Spontaneous Splenic Rupture in Chronic Myelomonocytic Leukemia Post G-CSF Administration

Promita Barua, Chandrashish Chakravarty, Soumya Bhattacharya, Lawni Goswami

Keywords : Acute abdomen, Chronic myelomonocytic leukemia, Granulocyte colony-stimulating factor, Hemoperitoneum, Shock, Splenic injury, Spontaneous splenic rupture

Citation Information : Barua P, Chakravarty C, Bhattacharya S, Goswami L. Spontaneous Splenic Rupture in Chronic Myelomonocytic Leukemia Post G-CSF Administration. 2022; 1 (2):46-47.

DOI: 10.5005/jp-journals-11006-0017

License: CC BY-NC 4.0

Published Online: 04-11-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Highlights Splenic rupture is a potentially life-threatening condition, often associated with trauma. Spontaneous splenic rupture (SSR) is very rare and is usually reported as secondary to some pathological conditions like infection (malaria, infectious mononucleosis), pancreatitis, sarcoidosis, or hematological malignancy. In this case report, we present an unusual presentation of SSR in a case of chronic myelomonocytic leukemia (CMML) who received granulocyte colony-stimulating factor (G-CSF) 10 days before presentation. Splenic rupture is one of the main causes of acute abdomen and should be considered in CMML or lymphoma. The history of G-CSF use is significant as it may cause SSR.

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  1. Rueda-Esteban R, Stozitzky Munoz N, Barrios Diaz M, et al. Spontaneous splenic rupture in a patient with chronic myeloid leukemia: a case report. Int J Surg Case Rep 2020;66:122–125. DOI: 10.1016/j.ijscr.2019.11.051
  2. Renzulli P, Hostettler A, Schoepfer AM, et al. Systematic review of a traumatic splenic rupture. Br J Surg 2009;96(10):1114–1121. DOI: 10.1002/bjs.6737
  3. Jafferbhoy S, Chantry A, Atkey N, et al. Spontaneous splenic rupture: an unusual presentation of CML. BMJ Case Rep 2011;2011:bcr0220113879. DOI: 10.1136/bcr.02.2011.3879
  4. Watring NJ, Wagner TW, Stark JJ. Spontaneous splenic rupture secondary to pegfilgrastim to prevent neutropenia in a patient with non-small-cell lung carcinom. Am J Emerg Med 2007;25(2):247–248. DOI: 10.1016/j.ajem.2006.10.005
  5. Kaniappan K, Lim CTS, Chin PW. Non-traumatic splenic rupture - a rare first presentation of diffuse large B-cell lymphoma and a review of the literature. BMC Cancer 2018;18(1):779. DOI: 10.1186/s12885-018-4702-1
  6. Lieberman ME, Levitt MA. Spontaneous rupture of the spleen: a case report and literature review. Am J Emerg Med 1989;7(1):28–31. DOI: 10.1016/0735-6757(89)90079-x
  7. Mohammed AM, Majid ZI, Villatoro EA. Spontaneous rupture of the spleen as a result of primary splenic lymphoma. J Surg Case Rep 2016,2016(1):rjv164. DOI: 10.1093/jscr/rjv164
  8. Taniguchi LU, Correia MD, Zampieri FG. Overwhelming post-splenectomy infection: narrative review of the literature. Surg Infect(Larchmt) 2014;15(6):686–693. DOI: 10.1089/sur.2013.051
  9. Rhodes A, Evans L, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock:2016. Crit Care Med 2017;45(3):486–552. DOI: 10.1097/CCM.0000000000002255
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