Indian Journal of Critical Care Case Report

Register      Login

VOLUME 1 , ISSUE 1 ( July-August, 2022 ) > List of Articles


DRESS Syndrome in Trauma Intensive Care Unit

Aayush Kulshrestha, Yudhyavir Singh

Keywords : Drug reactions, Drug reaction with eosinophilia and systemic symptoms, Phenytoin, Registry of severe cutaneous adverse reactions

Citation Information : Kulshrestha A, Singh Y. DRESS Syndrome in Trauma Intensive Care Unit. 2022; 1 (1):28-30.

DOI: 10.5005/jp-journals-11006-0011

License: CC BY-NC 4.0

Published Online: 31-08-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe adverse drug reaction characterized by a range of clinical manifestations, including an extensive skin rash, fever, lymphadenopathy, eosinophilia, and visceral organ involvement. The prolonged latency period and heterogeneous clinical profile with overlapping symptoms make the diagnosis of DRESS challenging as it mimics many common presentations, though mortality constitutes about 10%. Here we report a postoperative case of decompression craniectomy with acetabulum fracture discharged on phenytoin therapy presented with fever, rash, and breathing difficulty, which was later diagnosed as DRESS.

PDF Share
  1. Husain Z, Reddy BY, Schwartz RA. DRESS syndrome: part I. Clinical perspectives. J Am Acad Dermatol 2013;68(5):693.e1–693.e14. DOI: 10.1016/j.jaad.2013.01.033
  2. Choudhary S, McLeod M, Torchia D, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. J Clin Aesthet Dermatol 2013;6(6):31–37. PMID: 23882307.
  3. Kardaun SH, Mockenhaupt M, Roujeau JC. Comments on: DRESS syndrome. J Am Acad Dermatol 2014;71(5):P1000–P1000. DOI: 10.1016/j.jaad.2013.11.053
  4. Pannu AK, Adarsh MB, Sharma N. Not all febrile critical illness with rash is infective: drug reaction may be a mimic. Indian J Crit Care Med 2017;21(4):229–231. DOI: 10.4103/ijccm.IJCCM_397_16
  5. Fleming P, Marik PE. The DRESS syndrome: the great clinical mimicker. Pharmacotherapy 2011;31(3):332. DOI: 10.1592/phco.31.3.332
  6. Armin S, Chavoshzadeh Z, Rezaei N. Reply antiepileptic hypersensitivity syndrome and DRESS syndrome. Turk J Pediatr 2010;52(1):113. DOI: 10.1007/s11695-018-3199-7
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.