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VOLUME 1 , ISSUE 1 ( July-August, 2022 ) > List of Articles


Metformin and Acute Kidney Injury: Recipe for Disaster

Dhanushree Jayaramaiah, Padmakumar V Arayamparambil, Ganesh K Manjunatha

Keywords : Acute kidney injury, Hemodialysis, Metformin, Metformin-associated lactic acidosis, Type II diabetes mellitus

Citation Information : Jayaramaiah D, Arayamparambil PV, Manjunatha GK. Metformin and Acute Kidney Injury: Recipe for Disaster. 2022; 1 (1):13-15.

DOI: 10.5005/jp-journals-11006-0005

License: CC BY-NC 4.0

Published Online: 31-08-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Type II diabetes is a common disease worldwide and, metformin is one of the first line of drugs used in its treatment. Metformin elimination is mainly through the kidney; hence when the patient develops dehydration and acute kidney injury, it will lead to life-threatening lactic acidosis. Hemodialysis improves the patient's condition rapidly. We would like to present two patients who were on metformin and developed life-threatening lactic acidosis with hemodynamic instability following an episode of acute gastroenteritis and acute kidney injury. Hemodialysis hastened the recovery emphasizing the need for early identification and treatment.

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